Expression profiling the developing mammalian enteric nervous system identifies novel markers and candidate Hirschsprung disease genes
نویسندگان
چکیده
منابع مشابه
Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes.
The enteric nervous system (ENS) is composed of neurons and glial cells, organized as interconnected ganglia within the gut wall, which controls peristalsis of the gut wall and secretions from its glands. The Ret receptor tyrosine kinase is expressed throughout enteric neurogenesis and is required for normal ENS development; humans with mutations in the RET locus have Hirschsprung disease (HSCR...
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†Biozentrum and Swiss Institute of Bioinformatics, 4056 Basel; Switzerland; ‡Genomics Platform, National Center of Competence in Research Frontiers in Genetics, Université de Genève/CMU, 1211 Geneva 4, Switzerland; and §Group d’Etude de la Reproduction chez le Male-Institut National de la Santé et de la Recherche Médicale U. 435, Université de Rennes I, Campus de Beaulieu, 35042 Rennes cedex, B...
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The development of the enteric nervous system was examined in fetal mice. Synthesis of [3H] acetylcholine ([3H]ACh) from [3H]choline and acetylcholinesterase histochemistry were used as phenotypic markers for cholinergic neurons, while the radioautographic detection of the specific uptake of [3H]serotonin (5-[3H]HT) and immunocytochemical staining with antiserum to 5-HT marked serotonergic neur...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2007
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2007.03.653